The winger will replace Darren Ambrose with Fortune starting alongside Paddy McCarthy at the heart of the defence.
Boss Alan Pardew will go for a 4-4-2 formation and its expected that Chris Iwelumo will start upfront alongside Luke Varney.
Possible side for Blackpool: Weaver, Moutaouakil, Fortune, McCarthy, Youga, Sam, Zheng, Holland(c), Thomas, Varney, Iwelumo
Subs: Randolph, Semedo, Bougherra, McLeod, Ambrose