Powell has recovered from an ankle injury and could replace the injured Grant Basey.
Addicks boss Alan Pardew could also move Danny Mills to the left, and play either Yassin Moutaouakil or Madjid Bougherra at right back.
Pardew will also go back to a 4-4-2 formation which will see Luke Varney start in place of Lloyd Sam.
Possible side for Burnley: Weaver, Mills, Sodje, Fortune, Powell, Thomas, Semedo, Zheng, Reid (c), Varney, Iwelumo
Subs: Randolph, Bougherra, Holland, McLeod, Sam