The on-loan West Ham striker missed Tuesday night's defeat at Rochdale with an ankle injury but hopes to be fit.
Nouble may be a straight swap for Joe Anyinsah in attack after the former Carlisle forward picked up an ankle knock at Spotland.
Paul Benson and Liverpool loanee Nathan Ecclestone are manager Chris Powell`s other options to partner 20-goal frontman Bradley Wright-Phillips.
Powell will be tempted to make changes after admitting the midweek reverse had ended any hopes they had of making the play-offs.
Winger Johnnie Jackson (Achilles) and defender Kelly Youga (knee) remain sidelined while rookie full-back Carl Jenkinson is likely to be overlooked again after turning down a new contract.