The left-back pulled out of the Wales Under 21 squad with a hamstring strain but is fit enough to start against the Royals.
Therry Racon is out for three months with a broken metatarsal, so Addicks boss Alan Pardew has to choose between Matt Holland and Jonjo Shelvey to partner home debutant Nicky Bailey in the centre of midfield.
Yassin Moutaouakil could make his first league start of the season in place of Jose Semedo at right-back.
Possible side for Reading: Weaver, Moutaouakil, Fortune, Hudson(c), Basey, Sam, Bailey, Holland, Bouazza, Gray, Varney
Subs: Elliot, Dickson, Shelvey, Semedo, Ambrose