Therry Racon is out for three months with a broken metatarsal, so Addicks boss Alan Pardew has to choose between Matt Holland and Jonjo Shelvey to partner home debutant Nicky Bailey in the centre of midfield.
Yassin Moutaouakil could make his first league start of the season in place of Jose Semedo at right-back.
Possible side for Reading: Weaver, Moutaouakil, Fortune, Hudson(c), Basey, Sam, Bailey, Holland, Bouazza, Gray, Varney
Subs: Elliot, Dickson, Shelvey, Semedo, Ambrose